ABCB1 expression in peptic ulcer patients and its connection with H. pylori Infection

Glycoprotein P, encoded by the ABCB1 gene, plays an important role in gastric mucosa homeostasis and can influence the eradication therapy outcome in H. pylori-infected individuals. In the study we examined the ABCB1 expression level in 128 peptic ulcer patients by real-time PCR. There was no correlation between gene expression and the presence of H. pylori or the H. pylori infection intensity. The expression level did not differ between women and men. However, the levels were higher in patients who were over 54 years old than those who were aged up to 54 years old. As ABCB1 expression is largely determined by genetic polymorphisms, in the future, expression data will be related to the patients' ABCB1 genotypes.