Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The SILVER Platter for Patients with Inflammatory Bowel Disease (IBD): An IBD Pharmacy Technician-Led Subcutaneous Biologic Home Delivery Service Is Associated with Sustained Improvement in Adherence and Active Health Management.

Digestive diseases and sciences·2026
Same author

Examining attitudes to intestinal ultrasound in inflammatory bowel disease: a national survey of Australian gastroenterologists.

Therapeutic advances in gastroenterology·2026
Same author

Interpretable Deep Learning for Single-Molecule Nanopore Fingerprinting Using Physics-Guided Preprocessing.

ACS sensors·2026
Same author

MicroRNA spatial profiling for assessing drug efficacy in <i>BRCA1</i> -related triple-negative breast tumors.

bioRxiv : the preprint server for biology·2026
Same author

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution.

Nature communications·2026
Same author

High-Concentration Antibody Formulation via Solvent-Based Dehydration.

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Apr 25, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

15.7K

Synthesis of colloidal microgels using oxygen-controlled flow lithography.

Harry Z An1, H Burak Eral, Lynna Chen

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. pdoyle@mit.edu.

Soft Matter
|August 15, 2014
PubMed
Summary

Researchers developed a novel stop-flow lithography method to create custom-shaped colloidal microparticles. This technique allows for precise control over particle size and shape, enabling new applications in microfluidics and cell interactions.

More Related Videos

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
09:34

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

3.5K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.0K

Related Experiment Videos

Last Updated: Apr 25, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

15.7K
Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
09:34

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

3.5K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.0K

Area of Science:

  • Materials Science
  • Microfluidics
  • Biophysics

Background:

  • Fabricating microparticles with controlled shapes and sizes is crucial for various applications.
  • Existing methods often lack the flexibility to produce arbitrary 2D-extruded shapes or achieve very small dimensions.

Purpose of the Study:

  • To develop a versatile synthesis approach for fabricating colloidal microparticles with arbitrary 2D-extruded shapes.
  • To achieve precise control over particle dimensions, including sub-micron out-of-plane sizes.
  • To investigate the diffusion and flow properties of these microparticles in different environments.

Main Methods:

  • Utilized stop-flow lithography (SFL) for microparticle synthesis.
  • Modulated oxygen inhibition during synthesis to control particle dimensions.
  • Employed Brownian diffusion measurements and confocal microscopy to determine particle size.
  • Studied hindered diffusion near a solid surface and particle flow in microvascular networks.

Main Results:

  • Successfully fabricated colloidal microparticles with arbitrary 2D-extruded shapes.
  • Achieved previously unattainable particle sizes, with out-of-plane dimensions as small as 0.8 μm.
  • Demonstrated hindered diffusion of microdiscs near a surface, consistent with theoretical predictions.
  • Showcased particle passage through endothelial cell-formed microvascular networks under low hydrostatic pressure.

Conclusions:

  • The developed SFL platform offers a versatile method for creating shape- and size-controlled colloidal microparticles.
  • These microparticles exhibit predictable diffusion and flow behaviors relevant to biological systems.
  • The platform opens avenues for on-chip studies on particle geometry effects in microfluidic and cellular contexts.