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Complement membrane attack complex is related with immune-mediated necrotizing myopathy.

Lu Cong¹, Chuan-Qiang Pu¹, Qiang Shi¹

¹Department of Neurology, The Chinese PLA General Hospital Beijing, China.

International Journal of Clinical and Experimental Pathology

|August 15, 2014

Summary

This summary is machine-generated.

Complement membrane attack complex (C5b-9) is highly expressed in necrotizing myopathy (NM) muscle fibers and blood vessels, suggesting a role in NM pathogenesis. Further research is needed to clarify its exact contribution.

Keywords:

C5b-9 Necrotizing myopathy complement membrane attack complex endothelial cell muscle fiber

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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

Area of Science:

Immunology
Neurology
Pathology

Background:

Necrotizing myopathy (NM) is a severe muscle disease.
The role of the complement system in NM pathogenesis is not fully understood.

Purpose of the Study:

To investigate the expression of complement membrane attack complex (C5b-9) in skeletal muscle of NM patients.
To explore the relationship between C5b-9 and NM.

Main Methods:

Immunohistochemistry was used to detect C5b-9 expression in muscle biopsies from 13 NM patients and controls.
Serum creatine kinase (CK) and L-lactate dehydrogenase (LDH), electromyogram, and muscle pathology were assessed.

Main Results:

C5b-9 expression was prominent in necrotic muscle fibers and blood vessels in NM patients.
C5b-9 was also found in vascular endothelial cells and smooth muscle.
C5b-9 intensity did not correlate with elevated serum CK levels.

Conclusions:

C5b-9 is strongly expressed in necrotic muscle fibers and blood vessels in NM.
C5b-9 may play a significant role in the pathogenesis of necrotizing myopathy.