Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Association Areas of the Cortex01:21

Association Areas of the Cortex

10.1K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
10.1K
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

975
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
975
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.7K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.7K
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

39
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
39

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New onset refractory status epilepticus (NORSE) versus refractory status epilepticus not meeting NORSE criteria: A comparative clinical and electroencephalography-based study.

Epilepsia·2026
Same author

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions.

Annals of clinical and translational neurology·2026
Same author

Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')<sub>2</sub>-Modified Graphene Field-Effect Biosensor.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Network-based disease fingerprinting with neuroinflammation PET imaging.

Journal of neuroinflammation·2026
Same author

Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling.

Neurology·2026

Related Experiment Video

Updated: Apr 25, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

14.1K

Damage to the Salience Network and interactions with the Default Mode Network.

Sagar R Jilka1, Gregory Scott2, Timothy Ham3

  • 1Computational, Cognitive and Clinical Neuroimaging Laboratory, Centre for Neuroscience, Division of Experimental Medicine, Imperial College London, London, W12 0NN, United Kingdom, Department of Psychology, Goldsmiths College, University of London, SE14 6NW, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 15, 2014
PubMed
Summary

Damage to the Salience Network (SN) impairs cognitive control by disrupting interactions with the Default Mode Network (DMN). This study shows SN damage reduces functional connectivity crucial for attention and cognitive tasks.

Keywords:
Default Mode Networkfunctional connectivitypsychophysiological interactionssalience networktraumatic brain injury

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

17.2K
Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

12.4K

Related Experiment Videos

Last Updated: Apr 25, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

14.1K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

17.2K
Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

12.4K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroimaging

Background:

  • Interactions between the Salience Network (SN) and Default Mode Network (DMN) are critical for cognitive control.
  • Previous research suggests traumatic brain injury (TBI) affecting SN white matter tracts impacts DMN function.

Purpose of the Study:

  • To investigate the causal relationship between SN damage and altered DMN interactions during motor control tasks.
  • To examine how white matter damage within the SN affects functional connectivity (FC) between the SN and DMN.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to study response inhibition (Stop Signal Task) and motor response switching in healthy controls and TBI patients.
  • Analysis focused on functional connectivity (FC) between the right anterior insula (rAI) of the SN and the DMN.

Main Results:

  • Healthy subjects showed transient increases in rAI-DMN FC during response inhibition and switching.
  • TBI patients with SN damage exhibited blunted or absent rAI-DMN FC changes during these tasks.
  • The extent of SN tract damage correlated negatively with the strength of rAI-DMN FC.

Conclusions:

  • Cognitive control, particularly attentional focus on external stimuli, relies on dynamic coupling between the SN and DMN.
  • Damage to SN white matter tracts disrupts this coupling, leading to impaired cognitive control.
  • Findings support a model where the SN directs the DMN's activity based on attentional demands.