Related Experiment Video
Updated: Apr 25, 2026

07:30
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
8.4K
Cannabis use and suicidal ideations in high-school students
Henri Chabrol1, Tiffany Melioli1, Nelly Goutaudier1
1Université de Toulouse, France.
Addictive Behaviors
|August 16, 2014
Summary
Cannabis use did not predict suicidal ideations in adolescents when controlling for personality disorders. This finding suggests personality traits, not cannabis, may explain the link between substance use and suicidality.
Area of Science:
- Psychiatry
- Adolescent Health
- Substance Use Research
Background:
- The relationship between adolescent cannabis use and suicidal ideations is inconsistent in existing literature.
- Previous studies may not have adequately controlled for confounding factors, such as personality disorder traits.
- Borderline and psychopathic personality traits are associated with both cannabis use and suicidality.
Purpose of the Study:
- To investigate the association between cannabis use and suicidal ideations in adolescents.
- To determine if personality disorder traits mediate or confound this relationship.
- To control for borderline and psychopathic personality traits in the analysis.
Main Methods:
- A sample of 972 high-school students participated in the study.
- Participants completed self-report questionnaires assessing cannabis use, suicidal ideations, depressive symptoms, social anxiety symptoms, and personality disorder traits.
- Statistical analyses were performed to examine the predictive value of cannabis use on suicidal ideations, adjusting for personality traits.
Main Results:
- Cannabis use was not found to be a significant independent predictor of suicidal ideations.
- This finding remained consistent after adjusting for confounding personality traits in the total sample.
- The subsample of cannabis users also showed no significant association between cannabis use and suicidal ideations when controlling for personality traits.
Conclusions:
- The study suggests that cannabis use alone is not an independent risk factor for suicidal ideations in adolescents.
- Personality disorder traits, such as borderline and psychopathic traits, may be crucial confounding factors that explain the observed association.
- Future research and clinical interventions should consider personality traits when assessing suicide risk in adolescents who use cannabis.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
1.1K
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
1.1K
Stress and Mental Health
1.6K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.6K
Hallucinogens and Psychedelics
1.1K
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
1.1K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
1.4K
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.4K
Stimulants
1.4K
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
1.4K
Stress Prevention and Stress Management Techniques IV
364
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
364

