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Updated: Apr 25, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K

[Does the prescribing of antibiotics in paediatrics improve after a multidisciplinary intervention?]

Pilar Lalana-Josa1, Blanca Laclaustra-Mendizábal2, M Mercedes Aza-Pascual-Salcedo3

  • 1Centro de Salud Oliver, Sector Zaragoza III, Servicio Aragonés de Salud, Zaragoza, España.

Enfermedades Infecciosas Y Microbiologia Clinica
|August 16, 2014
PubMed

Insights

A multi-faceted intervention aimed to reduce antibiotic use in children. While prescribing decreased, the study found no statistically significant difference between intervention and control groups, highlighting the need for continued strategies.

Area of Science:

  • Public Health
  • Pediatrics
  • Infectious Diseases

Background:

  • Antibiotic overuse is a significant driver of antimicrobial resistance.
  • Children aged 1-4 years in Aragon, Spain, exhibit the highest antibiotic prescription rates, exceeding 60%.

Purpose of the Study:

  • To assess the impact of a multi-faceted intervention on Primary Care pediatricians.
  • To reduce antibiotic use and improve prescribing practices for pediatric outpatients.

Main Methods:

  • Analysis of outpatient antimicrobial prescribing patterns before and after an intervention.
  • Intervention included education on infectious diseases, communication skills, rapid strep testing, and parent resources.
  • A control group received no educational intervention.

Main Results:

  • Antibiotic prescribing reduced from 19.17 to 14.36 DID in the intervention group, versus 19.84 to 16.02 DID in controls.
  • Prescribing of macrolides and broad-spectrum penicillins decreased in both groups.
  • The observed decrease in the intervention group was not statistically significant.

Conclusions:

  • Antibiotic prescribing declined, but no statistically significant difference was found between intervention and control groups.
  • Pediatricians reported high satisfaction with the intervention, suggesting its potential value.
  • Continued implementation of similar strategies is recommended to optimize outpatient antibiotic use.
Abstract

Keywords:
Antibiotic useAtención primariaEstrategias de intervenciónIntervention strategiesPaediatricsPediatríaPrimary healthcareUtilización de antibióticos

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