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Updated: Apr 25, 2026
07:59
An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
Published on: March 22, 2018
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Cell-intrinsic timing in animal development.
Eric G Moss1, Jennifer Romer-Seibert
1Department of Molecular Biology, Rowan University, Stratford, NJ, USA.
Wiley Interdisciplinary Reviews. Developmental Biology
|August 16, 2014
Summary
Cells control their developmental timing through internal molecular mechanisms, similar to those in C. elegans, suggesting universal components in cell fate succession and neural development.
Area of Science:
- Developmental biology
- Cell biology
- Neuroscience
Background:
- Cellular behavior sequence is crucial for development.
- Examples include animal nervous system development and nematode development.
Purpose of the Study:
- To elucidate molecular mechanisms of cell fate succession.
- To explore connections between cell-intrinsic timing and neural development.
Main Methods:
- Investigating cell division and differentiation sequences.
- Analyzing heterochronic gene pathways in model organisms.
Main Results:
- Identified molecular factors and regulatory dynamics in cell fate succession.
- Found homologs of worm heterochronic factors in neural development.
Conclusions:
- Cell-intrinsic timing mechanisms may be widespread.
- Potential for universal components in timing mechanisms across species.
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