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Related Concept Videos

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Updated: Jan 26, 2026

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy
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Multiplexed gold nanorod array biochip for multi-sample analysis.

Yanyan Wang1, Liang Tang1

  • 1Department of Biomedical Engineering, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.

Biosensors & Bioelectronics
|August 16, 2014
PubMed
Summary
This summary is machine-generated.

This study presents a gold nanorod (GNR) multiplex biochip for label-free biosensing. The chip enables simultaneous detection of multiple analytes, offering a versatile platform for high-throughput protein analysis.

Keywords:
Gold nanorod biochipHigh throughput assayMultiplex biosensingNanoarraySurface plasmon resonance

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Area of Science:

  • Nanotechnology
  • Biotechnology
  • Materials Science

Background:

  • Localized surface plasmon resonance (LSPR) of gold nanorods (GNRs) offers label-free optical biosensing.
  • The aspect ratio (AR) of GNRs dictates LSPR band maxima, enabling multiplexing by using GNRs with distinct spectral peaks.

Purpose of the Study:

  • To develop a robust chip-based format for GNR multiplexed biosensing.
  • To demonstrate simultaneous detection of multiple analytes using GNRs with different aspect ratios.

Main Methods:

  • Assembling GNRs with AR 2.6 and 4.5 onto thiol-terminated substrates.
  • Functionalizing GNRs with specific antibodies to create a multiplex biochip.
  • Measuring human IgG and rabbit IgG concentrations by monitoring spectral shifts at distinct resonance peaks.

Main Results:

  • Simultaneous detection of human and rabbit IgG was achieved with minimal cross-reactivity.
  • Calibration curves showed a linear relationship between spectral shift and analyte concentration.
  • The GNR nanoarray chip demonstrated independent function of each GNR dot as a multiplexed sensor.

Conclusions:

  • The GNR multiplex biochip provides a simple and versatile platform for label-free, simultaneous multi-analyte detection.
  • This technology represents a new paradigm for high-throughput protein biochip development in nano-biosensing.
  • The chip format, coupled with microplate readers, facilitates large-scale assays with concurrent multi-analyte detection per sample.