Related Experiment Video
Updated: Apr 25, 2026

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis
Published on: January 6, 2016
Simultaneous voltammetric determination of paracetamol and ascorbic acid using a boron-doped diamond electrode
Katarzyna Tyszczuk-Rotko1, Ilona Bęczkowska1, Magdalena Wójciak-Kosior2
1Faculty of Chemistry, Department of Analytical Chemistry and Instrumental Analysis, Maria Curie-Skłodowska University, 20-031 Lublin, Poland.
Abstract:
The paper describes the fabrication and application of a novel sensor (a boron-doped diamond electrode modified with Nafion and lead films) for the simultaneous determination of paracetamol and ascorbic acid by differential pulse voltammetry. The main advantage of the lead film and polymer covered boron-doped diamond electrode is that the sensitivity of the stripping responses is increased and the separation of paracetamol and ascorbic acid signals is improved due to the modification of the boron-doped diamond surface by the lead layer. Additionally, the repeatability of paracetamol and ascorbic acid signals is improved by the application of the Nafion film coating. In the presence of oxygen, linear calibration curves were obtained in a wide concentration range from 5×10(-7) to 2×10(-4) mol L(-1) for paracetamol and from 1×10(-6) to 5×10(-4) mol L(-1) for ascorbic acid. The analytical utility of the differential pulse voltammetric method elaborated was tested in the assay of paracetamol and ascorbic acid in commercially available pharmaceutical formulations and the method was validated by high performance liquid chromatography coupled with diode array detector.
More Related Videos
Related Concept Videos
Voltammetric Techniques: Pulse Voltammetry
Voltammetric Techniques: Linear-Scan (E vs Time)
Voltammetric Techniques: Cyclic Voltammetry
Voltammetry: Stripping Methods
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...
Voltammetry: Factors Affecting Measurements
Potentiometry: Membrane Electrodes

