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Updated: Apr 25, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Capsaicin cough threshold test in diagnostics.

Teet Pullerits¹, Ewa Ternesten-Hasséus¹, Ewa-Lena Johansson²

¹Department of Respiratory Medicine and Allergology, The Sahlgrenska Academy, University of Gothenburg, Sweden.

Respiratory Medicine

|August 18, 2014

Summary

This summary is machine-generated.

Patients with sensory hyperreactivity (SHR) and chronic cough exhibit increased capsaicin cough sensitivity. A single-breath capsaicin test effectively distinguishes these patients from healthy controls, with C5 concentration being optimal for diagnostics.

Keywords:

Capsaicin Chronic cough Cough hypersensitivity syndrome Sensory hyperreactivity Single-breath method Threshold test

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Area of Science:

Respiratory Medicine
Clinical Physiology

Background:

A subset of patients with chronic cough experience respiratory symptoms triggered by environmental irritants.
Sensory hyperreactivity (SHR) is a proposed diagnosis for this group, identifiable via capsaicin inhalation tests.

Purpose of the Study:

To assess the efficacy of a single-breath, dose-response capsaicin threshold test in differentiating patients with SHR from healthy controls.
To evaluate the diagnostic capability of this method for sensory hyperreactivity in chronic cough.

Main Methods:

A single-breath, dose-response capsaicin cough threshold test was administered to 46 patients with chronic cough and SHR.
Capsaicin concentrations to elicit 2 (C2), 5 (C5), and 10 (C10) coughs were recorded.
Twenty-nine healthy controls were tested using the same threshold method.

Main Results:

Patients with SHR demonstrated significantly lower C2, C5, and C10 values compared to controls.
Receiver operating characteristic curve analysis indicated excellent discriminatory ability for C5 and C10.
Sensitivity and specificity calculations confirmed the test's effectiveness.

Conclusions:

The single-breath, dose-response capsaicin test confirms increased capsaicin cough sensitivity in patients with SHR and chronic cough.
Established limits for cough reactions can aid in diagnostics and research for sensory hyperreactivity.
The C5 concentration is identified as the most suitable measure for research and differential diagnosis.