The NEuroCOUGH Chronic Cough Registry: a protocol for a pan-European observational study
Peter S P Cho1,2, Surinder S Birring1,2, Clíona McDowell3
1Department of Respiratory Medicine, King's College Hospital NHS Foundation Trust, London, UK.
ERJ Open Research
|September 24, 2025
Summary
The NEuroCOUGH registry is Europe's first prospective study collecting data on chronic cough patients. This initiative aims to improve understanding and treatment of chronic cough by analyzing comprehensive clinical and physiological data.
Area of Science:
- Respiratory Medicine
- Clinical Research
- Epidemiology
Background:
- Chronic cough is a prevalent and challenging clinical issue.
- Existing expertise in cough management is fragmented across Europe.
- A need exists to consolidate data for a deeper understanding of chronic cough.
Purpose of the Study:
- To establish the first pan-European prospective observational registry for chronic cough.
- To collect comprehensive clinical, physiological, and biological data.
- To enhance understanding of chronic cough phenotypes, disease burden, and natural history.
Main Methods:
- Recruitment of adult patients (≥18 years) with cough >8 weeks duration.
- Exclusion of current/recent smokers and those with obstructive spirometry.
- Prospective observational study with 12-monthly follow-up for 36 months across 13 European sites.
Main Results:
- The NEuroCOUGH registry is established as a significant clinical and research resource.
- Comprehensive data on chronic cough, its impact, and outcomes are being collected.
- The study aims to recruit 2500 patients by 2026.
Conclusions:
- The NEuroCOUGH registry will advance the understanding of chronic cough.
- It will facilitate the development of specialist cough clinics and clinical trial infrastructure.
- Ultimately, this initiative aims to improve patient care for chronic cough.
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