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Updated: Apr 25, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Ultrathin core-sheath fibers for liposome stabilization
Zhuang Li1, Hongliang Kang2, Qinmei Li1
1State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
Ultrathin core-sheath fibers with small unilamellar vesicles (SUVs) in the core were prepared by coaxial electrospinning. SUVs/sodium hyaluranate (HA-Na)/water and polyvinylpyrrolidone (PVP)/ethanol solutions were used as core and sheath fluid in electrospinning, respectively. The ultrathin fibers were characterized by scanning and transmission electron microscopy (SEM and TEM) and laser scanning confocal microscopy (LSCM). The SUVs were successfully encapsulated in the core HA-Na matrix of the ultrathin fibers and are in the elliptic shape. The SUVs encapsulated in the core matrix of the ultrathin fibers have an excellent stability. The SUVs embedded in the ultrathin fibers are stable. When the ultrathin fibers were re-dissolved in water after one-month storage at room temperature, the rehydrated SUVs have the similar size and size distribution as the as-prepared SUVs. The liposome-loaded ultrathin fiber mats have the promising applications in wound healing materials.
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