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Identification of molecular target of diallyl trisulfide in leukemic cells
Shun Suda1, Kazunari Watanabe, Yuki Tanaka
1a Department of Chemistry and Life Science , College of Bioresource Sciences, Nihon University , Fujisawa , Japan.
Bioscience, Biotechnology, and Biochemistry
|August 19, 2014
Abstract:
To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27). Hsp27 is suggested to be one of the molecular target of DATS in U937.
