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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Related Experiment Video

Updated: Apr 25, 2026

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
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MicroRNAs and ethanol toxicity.

Rajesh C Miranda1

  • 1Department of Neuroscience and Experimental Therapeutics and Women's Health in Neuroscience Program, A&M Health Science Center, College of Medicine, Bryan, Texas, USA.

International Review of Neurobiology
|August 19, 2014
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene networks and are implicated in alcohol

Keywords:
Acute toleranceCirculating miRNAsDNA methylationEpigeneticsTeratologyTransgenerational epigeneticsmiRNAs

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Area of Science:

  • Biochemistry and Molecular Biology
  • Epigenetics
  • Developmental Biology

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
  • They influence cellular development and adaptation.
  • miRNAs interact with the epigenome to control gene transcription and translation.

Purpose of the Study:

  • To review the role of miRNAs in the epigenetic regulation of gene networks.
  • To discuss the involvement of miRNAs in the effects of alcohol consumption.
  • To highlight the importance of miRNA-epigenome interactions for understanding alcohol-related disorders.

Main Methods:

  • Literature review of recent data on miRNA function and epigenetics.
  • Analysis of studies implicating miRNAs in alcohol's developmental and adult effects.
  • Synthesis of evidence on miRNA-epigenome interactions.

Main Results:

  • miRNAs are key epigenetic regulators of protein-coding gene networks.
  • Evidence links miRNAs to both developmental and adult consequences of alcohol exposure.
  • Understanding these interactions is crucial for etiology and treatment.

Conclusions:

  • miRNAs are integral to the epigenetic control of gene expression.
  • Alcohol consumption impacts cellular processes via miRNA-epigenome interactions.
  • Further research into these mechanisms may yield novel therapeutic strategies for alcohol teratology and addiction.