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Related Concept Videos

Magnetic Resonance Imaging01:24

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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
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Free-breathing multislice native myocardial T1 mapping using the slice-interleaved T1 (STONE) sequence.

Sebastian Weingärtner1,2, Sébastien Roujol1, Mehmet Akçakaya1

  • 1Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

Magnetic Resonance in Medicine
|August 19, 2014
PubMed
Summary

The novel STONE sequence accurately quantifies native myocardial T1 times during free breathing. This method offers improved precision and covers the entire ventricle, outperforming MOLLI in cardiac MRI.

Keywords:
MOLLIMyocardial T1 mappinginversion recoverymultislice

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Quantitative Myocardial Perfusion and Function

Background:

  • Accurate T1 mapping of the myocardium is crucial for diagnosing and monitoring cardiovascular diseases.
  • Existing T1 mapping techniques often struggle with respiratory motion artifacts, limiting their clinical utility.
  • Free-breathing techniques are desirable for patient comfort and reduced scan times.

Purpose of the Study:

  • To develop and validate a novel pulse sequence for free-breathing, multislice, native myocardial T1 mapping.
  • To assess the accuracy and precision of the new sequence compared to a standard method.

Main Methods:

  • The slice-interleaved T1 (STONE) sequence utilizes a single nonselective inversion pulse followed by selective excitations for different slices.
  • Prospective slice-tracking and retrospective image registration were employed to mitigate respiratory motion.
  • Numerical simulations, phantom experiments, and in vivo studies in 14 subjects were conducted, comparing STONE to the MOdified Look-Locker Inversion recovery (MOLLI) sequence.

Main Results:

  • Numerical simulations and phantom experiments demonstrated that the STONE sequence with a two-parameter fit yields more accurate T1 times than MOLLI, with comparable precision.
  • The three-parameter fit model further enhanced accuracy but reduced precision.
  • STONE T1 maps exhibited lower standard deviation, indicating higher precision, especially with the two-parameter fit.

Conclusions:

  • The STONE sequence enables accurate and precise quantification of native myocardial T1 times.
  • This novel sequence effectively covers the entire ventricle, offering a significant advantage over existing methods.
  • STONE represents a promising advancement for quantitative cardiovascular MRI.