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Related Experiment Video

Updated: Apr 25, 2026

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

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Published on: January 6, 2012

Thalidomide affects experimental endometriosis: a randomized controlled study in the rat.

Afshin Azimirad¹, Saeed Alborzi, Perikala Vijayananda Kumar

¹Laparoscopy Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The Journal of Obstetrics and Gynaecology Research

|August 19, 2014

Summary

Thalidomide shows promise for treating endometriosis in a rat model. This study found significant improvements in histopathology scores and inflammatory markers, suggesting therapeutic potential.

Keywords:

animal model endometriosis immunology randomized controlled trial thalidomide

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Published on: November 24, 2020

Area of Science:

Reproductive biology
Immunology
Pharmacology

Background:

Endometriosis is a chronic, inflammatory gynecological condition.
Current treatments for endometriosis have limitations.
Thalidomide's anti-inflammatory and anti-angiogenic properties warrant investigation for endometriosis.

Purpose of the Study:

To evaluate the efficacy of thalidomide in an experimental rat model of endometriosis.
To assess the impact of thalidomide on endometriosis lesion severity and associated inflammatory markers.

Main Methods:

A randomized, double-blind, controlled animal trial was conducted.
Endometriosis was surgically induced in Sprague-Dawley rats.
Rats received either thalidomide (22 mg/day) or a saline control for 6 weeks.
Histopathology, leukocyte/lymphocyte counts, and cytokine levels (IL-6, TNF-α, VEGF-A) were analyzed.

Main Results:

Thalidomide treatment significantly reduced histopathology scores compared to controls (P=0.035).
Statistically significant differences were observed in post-treatment leukocyte, lymphocyte, VEGF-A, and IL-6 levels between groups.
These findings suggest thalidomide modulates key inflammatory pathways involved in endometriosis.

Conclusions:

Thalidomide demonstrates therapeutic potential for experimental endometriosis in rats.
This study provides the first evidence of thalidomide's efficacy in an animal model of endometriosis.
Further research is warranted to explore thalidomide's clinical application in endometriosis management.