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A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer
Garima Sharma1, Pradeep Dua2, Subhash Mohan Agarwal1
1Bioinformatics Division, Institute of Cytology and Preventive Oncology, Noida-201301, India.
Current Genomics
|August 19, 2014
Summary
MicroRNAs (miRNAs) are key regulators in cervical cancer development. This review details 246 differentially expressed miRNAs and their validated targets, offering insights into novel diagnostic and therapeutic strategies for this prevalent cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Cervical cancer is a major global health concern for women.
- While HPV vaccines and screening have reduced incidence, new strategies are needed.
- MicroRNAs (miRNAs) play a critical role in cervical cancer's malignant transformation.
Purpose of the Study:
- To comprehensively review the role of miRNAs in cervical cancer.
- To consolidate information on differentially expressed miRNAs and their targets.
- To provide a reference for understanding miRNA deregulation in cervical cancer progression.
Main Methods:
- Systematic literature search of PubMed for articles on miRNA expression in cervical cancer.
- Compilation and analysis of data from 51 published articles.
- Identification of differentially expressed miRNAs, validated targets, and miRNA clusters.
Main Results:
- Detailed information on 246 differentially expressed miRNAs implicated in cervical cancer progression.
- Identification of over 40 miRNAs frequently reported for their regulatory roles.
- Analysis of 40 experimentally validated targets, causes of miRNA dysregulation, and their mechanisms across cancer stages.
Conclusions:
- miRNA deregulation is central to cervical cancer pathogenesis.
- Identified miRNAs and targets offer potential for prognostic and therapeutic applications.
- This review serves as a valuable resource for advancing cervical cancer research and treatment.
