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Methicillin-resistant Staphylococcus epidermidis.

W T Siebert, N Moreland, T W Williams

    Southern Medical Journal
    |November 1, 1978
    PubMed
    Summary
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    Methicillin resistance is increasing in Staphylococcus epidermidis infections. Cephalothin shows high susceptibility against both methicillin-susceptible and resistant strains, making it a potential replacement for methicillin.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Staphylococcus epidermidis commonly causes infections related to medical devices like prosthetic heart valves, orthopedic implants, and neurosurgical shunts.
    • Penicillinase-resistant penicillins, notably methicillin, have historically been the primary treatment and preventative drugs for S. epidermidis infections.
    • A growing concern is the increasing resistance of S. epidermidis isolates to methicillin and other penicillin-based antibiotics.

    Purpose of the Study:

    • To evaluate the susceptibility of Staphylococcus epidermidis isolates to cephalothin, particularly in the context of rising methicillin resistance.
    • To determine if cephalothin can serve as an effective alternative prophylactic and therapeutic agent for S. epidermidis infections.

    Main Methods:

    Related Experiment Videos

    • Antimicrobial susceptibility testing was performed on clinical isolates of Staphylococcus epidermidis.
    • The study assessed the resistance rates to methicillin among the isolates.
    • Susceptibility to cephalothin was determined for both methicillin-susceptible and methicillin-resistant S. epidermidis strains.

    Main Results:

    • In the laboratory setting, 41% of Staphylococcus epidermidis isolates exhibited resistance to methicillin.
    • All methicillin-susceptible S. epidermidis isolates demonstrated susceptibility to cephalothin.
    • A significant majority, 82%, of methicillin-resistant S. epidermidis isolates were also susceptible to cephalothin.

    Conclusions:

    • Cephalothin demonstrates broad-spectrum activity against Staphylococcus epidermidis, including methicillin-resistant strains.
    • Given the high prevalence of methicillin resistance, cephalothin should be considered as a replacement for methicillin.
    • Institutions experiencing high rates of methicillin-resistant S. epidermidis should prioritize cephalothin for prophylaxis and treatment.