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Updated: Apr 25, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Occurrence of Hashimoto's thyroiditis among the patients with Sydenham's chorea
Alper I Dai1, Seniz Demiryürek, Mehmet Keskin
11Department of Pediatrics, Division of Pediatric Neurology, Faculty of Medicine, University of Gaziantep , Gaziantep , Turkey.
Aim:
The purpose of this study was to examine the possible association of Hashimoto's thyroiditis (HT) with Sydenham's chorea (SC).
Materials And Methods:
A total of 25 SC patients and 25 patients with the diagnosis of HT were included in the study. Neurological, cardiac, radiological abnormalities, clinical findings, and biochemical analysis were evaluated.
Results:
Heart murmur as a result of mitral valve deformation was present in all SC group patients. No neurologic and cardiac abnormalities were noted in HT group. Serum thyroid-stimulating hormone (TSH), anti-thyroid peroxidase, and anti-thyroglobulin levels were found to be high in 4 patients of the SC group and called as SC with HT group. Significant elevation of serum TSH levels in SC with HT group (31.75 ± 3.71 μU/ml) was observed when compared to HT group (12.60 ± 4.24 μU/ml, p < 0.05).
Conclusion:
These results showed that HT can be occurred among the patients with SC with cardiac involvement.
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