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Related Experiment Video

Updated: Apr 25, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Self-referenced spectroscopy using plasmon waveguide resonance biosensor.

Farshid Bahrami¹, Mathieu Maisonneuve², Michel Meunier²

¹Department of Electrical and Computer Engineering, University of Toronto, Ontario, M5S 3G4, Canada.

Biomedical Optics Express

|August 20, 2014

Summary

This summary is machine-generated.

A novel plasmon waveguide resonance (PWR) sensor offers self-referenced biosensing by utilizing TM and TE polarizations. This allows accurate measurement of surface changes, unaffected by background refractive index variations.

Keywords:

(250.5403) Plasmonics (280.4788) Optical sensing and sensors

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Area of Science:

Plasmonics
Nanophotonics
Biosensing

Background:

Surface plasmon resonance (SPR) sensors are widely used for biosensing.
Conventional SPR sensors are sensitive to both surface binding events and bulk refractive index changes.
Decoupling these effects is crucial for accurate and reliable biosensing.

Purpose of the Study:

To design, fabricate, and test a plasmon waveguide resonance (PWR) sensor for self-referenced biosensing.
To demonstrate the ability of the PWR sensor to distinguish between bulk effects and surface effects.
To benchmark the performance of the PWR sensor against a conventional SPR sensor.

Main Methods:

Utilizing a plasmon waveguide resonance (PWR) sensor capable of supporting both TM and TE polarizations.
Employing multimode spectroscopy to analyze the distinct sensitivities of TM and TE modes.
Fabricating and testing a conventional surface plasmon resonance (SPR) sensor under identical conditions for comparison.

Main Results:

The PWR sensor successfully supports both TM and TE polarizations.
TM polarization exhibits high sensitivity to background refractive index variations (bulk effects).
TE polarization shows greater sensitivity to adlayer thickness changes (surface effects).
Simultaneous operation in both modes allows for decoupling of bulk and surface effects.

Conclusions:

The developed PWR sensor enables self-referenced biosensing by effectively separating bulk and surface effects.
This approach enhances the accuracy and reliability of biosensing measurements.
The PWR sensor demonstrates comparable or superior performance to conventional SPR sensors.