Research progress in structure-activity relationship of bioactive peptides

Area of Science:

• Biochemistry
• Medicinal Chemistry
• Materials Science

Background:

• Bioactive peptides are protein fragments with significant health benefits.
• They are crucial sources for novel biomedicine, energy applications, and high-performance materials.
• Key activities include antioxidant, antihypertensive, anticarcinogenic, antimicrobial, and immunomodulatory effects.

Purpose of the Study:

• To review the progress in understanding the structure-activity relationship (SAR) of bioactive peptides.
• To highlight the role of SAR in developing synthetic polymeric counterparts.
• To focus on antioxidant, angiotensin-I-converting enzyme-inhibitory, and anticarcinogenic peptides.

Main Methods:

• Literature review of studies published in the past decade.
• Analysis of structure-activity relationships for specific bioactive peptide classes.
• Examination of synthetic strategies and product development based on SAR.

Main Results:

• The SAR of bioactive peptides is fundamental for designing effective synthetic analogs.
• Established relationships guide the stereospecific synthesis and transformation of peptide products.
• Progress has been made in understanding SAR for antioxidant, ACE-inhibitory, and anticarcinogenic peptides.

Conclusions:

• The SAR of bioactive peptides is critical for innovation in biomaterials and pharmaceuticals.
• Continued research into SAR will drive the development of novel synthetic peptide-based products.
• This review provides a decade-long perspective on SAR advancements in key bioactive peptide categories.