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Updated: Apr 25, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
Proggananda Nath1, Ariful Basher2, Michiyo Harada3
1Medical Officer, Surya Kanta Kala-azar Research Centre, Mymensingh Medical College Hospital, Bangladesh.
Abstract:
Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension followed by shock and the other had facial angioedema with chest tightness during treatment. Both patients were managed with immediate action of injection: adrenaline, diphenhydramine and hydrocortisone. In our experience, AmBisome can cause severe hypersensitivity reactions that warrant proper support and close supervision.
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