Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

3.4K
Commitment is the  process whereby stem cells:
3.4K
Determination01:51

Determination

16.3K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
16.3K
Neurulation01:30

Neurulation

40.1K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RBMX functional retrocopy safeguards brain development in a species-dependent context.

Brain : a journal of neurology·2026
Same author

Cdk7 promotes neuritogenesis in cortical neurons and contributes to social behavior in mice.

Cellular and molecular life sciences : CMLS·2026
Same author

Developmental gene expression patterns driving species-specific cortical features.

Nature·2026
Same author

Protocol for whole-cell patch-clamp recording and post hoc identification of hippocampal CA2 pyramidal neurons in adult mouse brain slices.

STAR protocols·2026
Same author

Sex Differences and Survival Among COPD Patients in France: The Palomb Cohort.

International journal of chronic obstructive pulmonary disease·2026
Same author

Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation.

CPT: pharmacometrics & systems pharmacology·2026

Related Experiment Video

Updated: Apr 25, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.0K

Progenitor genealogy in the developing cerebral cortex.

Sophie Laguesse1, Elise Peyre, Laurent Nguyen

  • 1GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium.

Cell and Tissue Research
|August 22, 2014
PubMed
Summary
This summary is machine-generated.

This review explores progenitor cell relationships in the developing mammalian cerebral cortex. Understanding these neural progenitor dynamics is key to unraveling the mechanisms of corticogenesis.

More Related Videos

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

7.8K
Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 25, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.0K
Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

7.8K
Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.6K

Area of Science:

  • Developmental Neuroscience
  • Cell Biology
  • Histology

Background:

  • The mammalian cerebral cortex exhibits complex histological organization.
  • This organization arises from spatio-temporal stratification of stem and neural progenitor cells.
  • These progenitors generate diverse glial and neuronal subtypes during development.

Purpose of the Study:

  • To review current understanding of progenitor hierarchy and relationships in the developing cortex.
  • To discuss future research directions for understanding corticogenesis regulation.
  • To elucidate molecular and cellular mechanisms governing cerebral cortex development.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of progenitor cell filiations and contributions to neurogenesis.
  • Discussion of developmental mechanisms in cerebral corticogenesis.

Main Results:

  • Current views on progenitor hierarchy are summarized.
  • The contribution of progenitors to cortical neurogenesis is discussed.
  • Key research gaps in understanding corticogenesis are identified.

Conclusions:

  • Further research is needed to fully understand progenitor roles.
  • Elucidating molecular and cellular regulators is crucial for advancing corticogenesis knowledge.
  • This review provides a framework for future investigations into brain development.