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Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?
Takayuki Miki, Toshiyuki Tobisawa, Tatsuya Sato
1Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, South-1 West-16, Sapporo 060-8543, Chuo-ku, Japan. miura@sapmed.ac.jp.
Cardiovascular Diabetology
|August 22, 2014
Summary
Improved glycemic control in type 2 diabetes did not reverse abnormal ventricular repolarization. This study found that increased QT dispersion and Tpeak-Tend in diabetic patients persisted despite lower HbA1c levels.
Area of Science:
- Cardiology
- Endocrinology
- Medical Diagnostics
Background:
- Abnormal ventricular repolarization is a significant predictor of cardiovascular mortality.
- Patients with type 2 diabetes often exhibit altered cardiac repolarization patterns.
Purpose of the Study:
- To investigate whether improved glycemic control can reverse abnormal ventricular repolarization in patients with type 2 diabetes.
- To assess the impact of HbA1c reduction on repolarization indices.
Main Methods:
- Retrospective analysis of electrocardiogram (ECG) repolarization indices in 44 patients with type 2 diabetes and 44 age-matched healthy controls.
- Longitudinal follow-up of 36 diabetic patients to evaluate changes in repolarization during improved glycemic control.
Main Results:
- Type 2 diabetes patients showed significantly longer QT dispersion and Tpeak-Tend compared to controls, indicating increased ventricular repolarization heterogeneity.
- Despite a significant decrease in HbA1c levels during follow-up, QT dispersion and Tpeak-Tend did not show significant improvement.
- No correlation was found between changes in HbA1c and changes in QT dispersion or Tpeak-Tend.
Conclusions:
- Improved glycemic control over a relatively short follow-up period did not significantly reduce the increased heterogeneity of ventricular repolarization observed in type 2 diabetes patients.
- These findings suggest that other factors may contribute to or sustain repolarization abnormalities in type 2 diabetes beyond glycemic levels.
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