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Related Experiment Video

Updated: Apr 25, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Genetically engineered mouse models for drug development and preclinical trials.

¹Division of Convergence Technology, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 410-769, Republic of Korea.

Biomolecules & Therapeutics

|August 22, 2014

Summary

Genetically engineered mouse models (GEMMs) offer a powerful solution to improve drug discovery and preclinical trials. These advanced models enhance target identification and validation, increasing the success rate for new drug development.

Keywords:

Drug discovery Genetically engineered mouse models Preclinical trials RNAi mouse Targeted transgenesis

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Last Updated: Apr 25, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes

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Published on: June 15, 2017

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Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation

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Published on: May 5, 2023

Area of Science:

Biomedical research
Pharmacology
Genetics

Background:

Drug development faces high failure rates (80-90%) in preclinical trials, necessitating improved predictive tools.
In vivo animal models, particularly genetically engineered mouse models (GEMMs), are crucial for target identification and validation.
GEMMs allow for precise genetic modification, aiding in the study of gene function and disease mechanisms.

Purpose of the Study:

To review recent technologies for drug discovery and preclinical trials using GEMMs.
To highlight the application of targeted transgenesis and RNA interference (RNAi) mouse models.
To discuss the integration of inducible systems within GEMMs for enhanced experimental control.

Main Methods:

Review of scientific literature on genetically engineered mouse models.
Focus on targeted transgenesis and RNAi technologies in mice.
Analysis of inducible systems in conjunction with GEMMs for drug development.

Main Results:

GEMMs have become indispensable tools in drug discovery, significantly aiding in target validation.
Targeted transgenesis and RNAi technologies offer precise genetic manipulation capabilities.
Inducible systems enhance the utility of GEMMs by allowing temporal and spatial control of gene expression.

Conclusions:

Advancements in GEMM technologies are critical for increasing the success rate of drug development and preclinical trials.
The application of novel GEMMs is expected to drive future innovations in pharmaceutical research.
GEMMs provide a cost-effective and manageable in vivo approach to overcome drug development challenges.