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Updated: Apr 25, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Evaluation of relationship between cranial base angle and maxillofacial morphology in Indian population: A
Amit Bhattacharya1, Amarjitsingh Bhatia2, Dolly Patel3
1Department of Orthodontics, Government Dental College and Hospital, Ahmedabad, Gujarat, India.
Objective:
To investigate the role played by the cranial base flexure in influencing the sagittal and vertical position of the jaws in Indian population.
Materials And Methods:
Lateral cephalograms of 108 subjects were divided into three categories (Group A: NSAr > 125°, Group B: NSAr-120°-125°, Group C: NSAr < 120°) according to value of NSAr. Measurement of eight angular (SNA, SNB, NPg-FH, ANB, NAPg, SN-GoGn, Y-Axis, ArGo-SN) and seven linear (N-S, S-Ar, Ar-N, Ar-Pt A, Ar-Gn, Wits appraisal, N- Pt A) variables were taken.
Results:
Pearson correlation coefficient test was used to individually correlate angular and linear variables with NSAr for the whole sample as well as in individual group. Unpaired t-test was used to analyze the difference in the means of all the variables between the three groups. Significance was determined only when the confidence level was P < 0.05. Several parameters (SNB, NAPg, ANB, Y-Axis, GoGn-SN) showed significant positive correlation while others showed negative correlation (SNA, NPg-FH, N-S) with NSAr.
Conclusions:
This study show cranial base angle has a determinant role in influencing the mandibular position and it also affects both the mandibular plane angle and y-axis. Flattening of the cranial base angle caused a clockwise rotation of the mandible. The jaw relation tends to change from class III to class II, with progressive flattening of the cranial base and vice-versa.
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