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Childhood meningitis caused by Streptococcus bovis group: clinical and biologic data during a 12-year period in

Anne Beneteau1, Corinne Levy, Pierre Foucaud

  • 1From the *Department of Pediatrics, Centre Hospitalier de Versailles, Le Chesnay; †ACTIV, Association Clinique et Thérapeutique Infantile du Val de Marne, Saint Maur les Fossés; ‡GPIP, Pediatric Infectious Disease Group; §Clinical Research Center (CRC); ¶Department of Pediatrics, Centre Hospitalier Intercommunal de Créteil, Créteil; and ‖Department of Microbiology, Hôpital Cochin, Paris, France.

The Pediatric Infectious Disease Journal
|August 22, 2014
PubMed
Abstract

Insights

Bacterial meningitis (BM) in infants caused by Streptococcus bovis is rare, predominantly affecting premature newborns. Prompt antibiotic treatment proved effective, resulting in low morbidity and mortality rates.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Bacterial meningitis (BM) poses significant risks for children.
  • Streptococcus bovis is an uncommon cause of pediatric BM.
  • This study investigated BM cases in children using a national surveillance network.

Purpose of the Study:

  • To determine the epidemiologic, clinical, and biologic characteristics of Streptococcus bovis meningitis in children.
  • To assess the outcomes of treatment for this rare form of pediatric meningitis.

Main Methods:

  • Data collected from 227 pediatric wards and 168 microbiology departments across France (2001-2012).
  • Diagnosis of BM based on clinical signs, cerebrospinal fluid (CSF) analysis, and positive cultures/PCR.
  • Case identification for Streptococcus bovis meningitis in patients under 18 years.

Main Results:

  • 23 cases of S. bovis meningitis identified among 4806 BM cases (0.5%).
  • All affected patients were infants, with 73.9% being premature.
  • Streptococcus gallolyticus pasteurianus (type 2) was the predominant subtype (80%).
  • No deaths or neurological complications were reported with standard antibiotic therapy.

Conclusions:

  • S. bovis meningitis is a rare condition primarily impacting infants, especially premature ones.
  • Effective antibiotic regimens, including penicillin, cephalosporins, and aminoglycosides, lead to favorable outcomes.
  • The study highlights the low morbidity and mortality associated with S. bovis meningitis in pediatric patients.

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