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Updated: Apr 25, 2026
Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
Published on: July 11, 2016
Microarray analysis of intestinal immune-related gene expression in heat-stressed rats
Xiaoxi Liu1, Yaran Shi, Xiaolin Hou
1China Agricultural University-Beijing University of Agriculture Traditional Chinese Veterinary Medicine (CAU-BUA TCVM) Teaching and Research Team, College of Animal Science and Technology, Beijing University of Agriculture , Beijing .
Purpose:
This study aimed to investigate immune-related gene expression in rat small intestine after heat stress.
Materials And Methods:
Twelve Sprague Dawley (SD) rats were randomly divided into control and heat-stressed groups. Rats in both groups were housed at 25 °C with 60% relative humidity. The heat-stressed group was subjected to 40 °C for 2 h/day for 3 days. After heat stress, the mRNA expression profile of small intestine epithelial tissue was evaluated by microarray analysis.
Results:
A total of 23 genes related to immune responses were significantly altered, of which 12 genes were up-regulated and 11 genes were down-regulated.
Conclusions:
Microarray analysis demonstrated the JAK-STAT pathway had a potentially important role in the regulation of inflammation in the small intestine, and changes in antigen presentation might reduce intestinal immune responses after heat stress.
