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Experimental studies on the protective efficacy of a Pseudomonas aeruginosa vaccine
E S Stanislavsky1, L S Edvabnaya, O A Bandman
1I.I. Mechnikov Central Research Institute of Vaccines and Sera, Moscow,USSR.
Vaccine
|December 1, 1989
Abstract:
Pseudomonas aeruginosa vaccine (PV) containing cell proteins with molecular weight (Mr) 20,000-100,000 and up to 0.08% (w/v) admixture of lipopolysaccharide was obtained by water-salt extraction and subsequent ultrafiltration. PV protects mice against experimental P. aeruginosa infection, stimulates production of specific protective antibodies in rabbit and does not provoke obvious toxicity in laboratory animals.