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Ovarian hyperstimulation syndrome and thrombotic events
Yechiel S Mor1, Joseph G Schenker
1Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Summary
Ovarian hyperstimulation syndrome (OHSS) poses a significant risk of thromboembolism, particularly in infertile patients undergoing ovulation induction. Early thromboprophylaxis is crucial for those with thrombophilia and severe OHSS.
Area of Science:
- Reproductive Endocrinology
- Hematology
- Obstetrics & Gynecology
Background:
- Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovulation induction.
- Thromboembolic events are a significant concern in patients with OHSS.
Purpose of the Study:
- To review the existing literature on the association between OHSS and thromboembolism in infertile patients.
- To analyze the incidence, timing, and characteristics of thromboembolic events in OHSS patients.
Main Methods:
- A comprehensive literature search of the PubMed Database was conducted.
- Publications from 1965 to 2013 reporting cases of OHSS and thromboembolic phenomena were reviewed.
- Data from 140 retrieved cases were analyzed.
Main Results:
- Thromboembolic events occurred in 85% of cases during the first treatment cycle.
- Venous thrombotic events were frequently observed in unusual sites like jugular and subclavian veins.
- Pregnancy outcomes included singleton births, preterm deliveries, and indicated terminations.
Conclusions:
- Thrombotic phenomena represent the most severe complication of OHSS.
- Thromboprophylaxis is recommended for patients with thrombophilia who develop moderate-to-severe OHSS.
Keywords:
Anticoagulant therapyassisted reproductive technologyovarian hyperstimulation syndromethrombophiliathrombosisMore Related Videos
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