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Related Concept Videos

Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

365
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
365
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

377
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
377
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

393
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
393
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

849
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
849

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Related Experiment Videos

Gerontology in Five Images.

David J Ekerdt1

  • 1Gerontology Center, University of Kansas, Lawrence. dekerdt@ku.edu.

The Gerontologist
|August 23, 2014
PubMed
Summary
This summary is machine-generated.

This study suggests teaching gerontology using focal visuals can unify the field. Visual aids help synthesize complex aging concepts, promoting interdisciplinary understanding and addressing the field

Keywords:
HeterogeneityLife courseResponsibilityTeaching

Related Experiment Videos

Area of Science:

  • Gerontology
  • Educational Strategies
  • Interdisciplinary Studies

Background:

  • Gerontology faces challenges with disciplinary fragmentation.
  • A need exists for greater coherence within the field of gerontology.
  • Scott Bass highlighted the need for increased coherence in gerontology.

Purpose of the Study:

  • Propose gerontology teaching as a method to unify the field.
  • Utilize focal visuals to structure and disseminate gerontological knowledge.
  • Integrate diverse concepts within gerontology through a focused instructional approach.

Main Methods:

  • Selection of five key visual aids (images and charts) to represent core gerontological concepts.
  • Using these visuals as focal points for radiating and returning exposition of knowledge.
  • Suggesting a sixth visual to counteract negative perceptions of aging.

Main Results:

  • The selected visuals synthesize complex ideas on life course, senescence, health trajectories, cohort succession, and adult life uncertainties.
  • Common features in visuals include lifelong time flows and arc-like shapes.
  • The proposed teaching strategy aims to integrate knowledge effectively.

Conclusions:

  • Teaching gerontology through carefully selected visuals can enhance its coherence.
  • This approach can manage the field's disciplinary sprawl and integrate diverse content.
  • Visual pedagogy offers a powerful tool for understanding and teaching aging processes.