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Correlation between magnetic resonance imaging grading and pathological grading in meningioma
Bon-Jour Lin1, Kuan-Nein Chou, Hung-Wen Kao
1Department of Neurological Surgery.
Journal of Neurosurgery
|August 23, 2014
Summary
Preoperative MRI features like indistinct tumor-brain interface and heterogeneous enhancement can predict high-grade intracranial meningiomas. A new scoring scale aids in surgical planning and therapeutic strategy for these brain tumors.
Area of Science:
- Neurosurgery
- Neuroradiology
- Oncology
Background:
- Intracranial meningiomas are common primary brain tumors.
- Accurate preoperative grading is crucial for treatment planning.
Purpose of the Study:
- To identify specific preoperative MRI features correlating with meningioma pathological grade.
- To develop a predictive scoring model for enhanced surgical and therapeutic planning.
Main Methods:
- Retrospective analysis of 120 patients with intracranial meningiomas (2006-2012).
- Evaluation of preoperative MRI features against WHO histopathological grades (I, II, III).
- Multivariate logistic regression and quantitative scoring scale development.
Main Results:
- Advanced age (≥75 years), indistinct tumor-brain interface, capsular enhancement, and heterogeneous enhancement predicted higher-grade meningiomas.
- A quantitative scoring scale incorporating these features showed positive correlation with high-grade meningioma probability.
- The developed model effectively predicted advanced pathological grades.
Conclusions:
- The developed MRI-based scoring approach aids in differentiating high-grade meningiomas preoperatively.
- This tool can assist clinicians in optimizing therapeutic strategies and surgical planning for intracranial meningiomas.
