Related Experiment Video
Updated: Apr 25, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Effects of the hyperbaric oxygen on de novo bone formation during periosteal distraction
Berkay Tolga Suer1, Kerim Ortakoglu, Yilmaz Gunaydin
1From the *Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Haydarpasa Teaching Hospital; †Service of Dental Medicine, Medicana Hospital, Istanbul; §Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Etlik; ∥Department of Dental Medicine, Tatvan Military Hospital, Tatvan; ‡Private Practice, Ankara; and ¶Kasimpasa Military Hospital, Kasimpasa, Istanbul, Turkey.
Objective:
The purpose of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on de novo bone formation during periosteal distraction (PD).
Materials And Methods:
Periosteal distraction was performed in 24 mature male New Zealand rabbits using a custom-designed device placed on the lateral surface of the mandibular corpus. Twelve rabbits (group H) were given adjunctive HBO treatment, whereas 12 rabbits (group N) were kept in a normal environment (normobaric oxygen). After a 7-day latency period, the same distraction protocol was applied to both groups. However, the rabbits in group H were treated with pure oxygen at 2.4 atm absolute for 25 times. Both groups were further divided into 2 subgroups and killed after consolidation periods of 4 and 8 weeks. Photodensitometric and histologic analyses were performed to evaluate the newly formed bone.
Results:
There was no significant difference between the 4-week consolidated HBO group and the 8-week consolidated normobaric oxygen subgroup (P = 0.229). Moreover, there was better bone formation in the 8-week HBO group than in the 8-week control group.
Conclusion:
The results of this study indicate that PD with HBO could be used to increase the quality and the quantity of the bone newly formed by PD.
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