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Topical therapies in hyperhidrosis care.

David M Pariser1, Angela Ballard2

  • 1International Hyperhidrosis Society, Quakertown, PA 18951, USA; Department of Dermatology, Eastern Virginia Medical School, 601 Medical Tower, Norfolk, VA 23507, USA.

Dermatologic Clinics
|August 26, 2014
PubMed
Summary

Primary focal hyperhidrosis, affecting 3% of the US population, involves excessive sweating. Topical treatments like aluminum salts and anticholinergics, along with proper antiperspirant use, can effectively manage this condition.

Keywords:
Aluminum chlorideAluminum chloride hexahydrateAluminum saltsAluminum zirconium trichlorohydrexAntiperspirantsHyperhidrosis topical treatmentsTopical glycopyrrolate

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Area of Science:

  • Dermatology
  • Clinical Medicine

Background:

  • Primary focal hyperhidrosis impacts 3% of the US population, comparable to psoriasis prevalence.
  • Over half of these patients experience primary focal axillary hyperhidrosis, characterized by sweating exceeding thermoregulatory needs.

Purpose of the Study:

  • To review the efficacy of topical therapies for primary focal hyperhidrosis.
  • To highlight the role of antiperspirant application techniques in managing hyperhidrosis.

Main Methods:

  • Review of existing literature on topical treatments for hyperhidrosis.
  • Analysis of the mechanisms of action for aluminum salts and topical anticholinergics.
  • Evaluation of the impact of antiperspirant usage instructions.

Main Results:

  • Topical therapies, primarily aluminum salts, function by obstructing eccrine sweat ducts.
  • Topical anticholinergics offer an alternative treatment option.
  • Optimized application methods and timing of antiperspirants can enhance treatment effectiveness.

Conclusions:

  • Aluminum salts and topical anticholinergics are key treatments for hyperhidrosis.
  • Proper antiperspirant application is crucial and can be a standalone or adjunctive therapy for managing excessive sweating.