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Autism Spectrum Disorder01:19

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Association Between Antidepressants Use During Pregnancy and Autistic Spectrum Disorders: A Meta-analysis.

Theodor B Rais1, Alexandra Rais1

  • 1Dr. Rais is the Associate Professor of Psychiatry at the University of Toledo Medical Center, Toledo, Ohio; Ms. Rais is from the Public Health Masters Program at the University of Toledo, Health Science Campus, Toledo, Ohio.

Innovations in Clinical Neuroscience
|August 26, 2014
PubMed
Summary
This summary is machine-generated.

Maternal antidepressant use during pregnancy is linked to an increased risk of autistic spectrum disorders (ASD) in children. This meta-analysis confirms a positive association between prenatal antidepressant exposure and ASD development.

Keywords:
Antidepressantsautistic spectrum disordersmeta-analysisneurodevelopmental delayspregnancyr stats software

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • Studies suggest a correlation between prenatal antidepressant exposure and adverse neurodevelopmental outcomes in children.
  • Concerns exist regarding the potential for antidepressants to influence the development of autistic disorder symptoms.

Purpose of the Study:

  • To investigate the association between prenatal exposure to antidepressants and the development of autistic spectrum disorders (ASD) and neurodevelopmental delays.
  • To synthesize existing research on the impact of maternal antidepressant use during pregnancy on child neurodevelopment.

Main Methods:

  • A systematic literature search was conducted across databases including PUBMED, MEDLINE, PsycARTICLES, and ERIC.
  • Original articles published between January 1983 and May 2013 were reviewed for relevance.
  • A meta-analysis was performed on three selected pertinent studies.

Main Results:

  • The meta-analysis identified a positive association between antidepressant exposure in utero and autistic spectrum disorders.
  • The findings indicate a potential link between maternal antidepressant use and increased risk of ASD in offspring.

Conclusions:

  • Prenatal exposure to antidepressants is associated with an increased risk of autistic spectrum disorders.
  • Further research is warranted to fully understand the mechanisms and implications of this association.