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New briarane diterpenoids from Taiwanese soft coral Briareum violacea
Chia-Ching Liaw1, Yuan-Bin Cheng2, Yun-Sheng Lin3
1School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan. biogodas@hotmail.com.
Abstract:
Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data ((1)H- and (13)C-NMR, (1)H-(1)H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/ Cytochalasin B (fMLP/CB).
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