Related Experiment Video
Updated: Apr 25, 2026
Nerve-sparing Mid-urethral Obstruction NeMO in Female Small Rodents
Published on: April 25, 2017
Neuropathic bladder in the neonate
1Division of Urology, The Children's Hospital of Philadelphia, 3rd Flr Wood Center, 34th Street & Civic Center Boulevard, Philadelphia, PA 19104, USA.
Insights
Managing myelomeningocele in infants requires understanding bladder function for low-pressure storage and effective emptying. This approach helps prevent infections and promotes healthy kidney growth, often needing interventions like catheterization.
Area of Science:
- Pediatric Urology
- Neonatal Neurology
- Developmental Biology
Background:
- Myelomeningocele significantly impacts bladder function in infants.
- Understanding urinary storage and emptying is crucial for management.
- The primary goals are infection prevention and ensuring renal growth.
Purpose of the Study:
- To outline the principles of bladder management in neonates with myelomeningocele.
- To emphasize the role of urodynamic evaluation in risk stratification.
- To highlight common interventions for achieving optimal bladder function.
Main Methods:
- Review of current management strategies for neonatal myelomeningocele.
- Emphasis on urodynamic evaluation for assessing bladder storage and emptying.
- Discussion of therapeutic interventions including intermittent catheterization and pharmacotherapy.
Main Results:
- Effective bladder management aims for low-pressure storage and periodic emptying.
- Urodynamic evaluation stratifies neonates based on risk.
- Most patients will require interventions during their lifetime.
Conclusions:
- Optimal bladder management is essential for preventing urinary tract infections and promoting renal health in infants with myelomeningocele.
- Urodynamic assessment is a key tool for guiding management decisions.
- Intermittent catheterization and pharmacotherapy are vital components of long-term care.
Abstract:
The management of infants born with myelomeningocele depends on understanding how their bladder stores and empties urine. Storage at low pressure with effective emptying periodically throughout the day is the goal. Intervention is designed to impact on one or both of these processes so that infants can remain infection-free and at the same time allow for appropriate renal growth over time. Urodynamic evaluation plays an important role, so that neonates can be stratified according to their risk. Most patients require intermittent catheterization and pharmacotherapy to achieve these goals at some point in their lives.
More Related Videos
06:36A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
06:05Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
Published on: October 12, 2017
Related Concept Videos
01:26The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
01:23Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
01:30Neurulation
01:28Microbiota of the Urogenital Tract
01:20Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...