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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
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Interferons: Success in anti-viral immunotherapy
Fan-ching Lin1, Howard A Young1
1Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer, Research, National Cancer Institute, Frederick, MD 21702, USA.
Cytokine & Growth Factor Reviews
|August 27, 2014
Summary
Interferons (IFNs) are crucial antiviral glycoproteins. While effective for chronic infections like Hepatitis C and B, their potent immune modulation can cause side effects, necessitating careful patient monitoring.
Area of Science:
- Immunology
- Virology
- Pharmacology
Background:
- Interferons (IFNs) are key glycoproteins in host defense against viral pathogens.
- IFNs are classified into Type I, II, and III based on cell surface receptor structures.
- Their immune-modulating properties make them valuable for treating chronic viral infections.
Purpose of the Study:
- To review the therapeutic applications of interferons in managing chronic viral infections.
- To highlight the efficacy and limitations of Type I and Type III IFNs in treating Hepatitis B and C.
- To emphasize the need for cautious use and monitoring of IFN therapy due to potential side effects.
Main Methods:
- Literature review of studies on interferon classification, antiviral activity, and therapeutic use.
- Analysis of clinical trial data for Type I and Type III IFNs in Hepatitis B and C treatment.
- Synthesis of information on the immunomodulatory effects and adverse events associated with IFNs.
Main Results:
- Type I IFNs are standard care for Hepatitis C (HCV) and Hepatitis B (HBV).
- Type III IFN shows promise in Phase III trials for HCV treatment.
- IFN therapy, while effective, can lead to significant, systemic side effects in patients.
Conclusions:
- Interferons are potent antiviral agents with established roles in treating chronic viral infections.
- Careful patient monitoring is essential to manage side effects and ensure treatment efficacy.
- Balancing the benefits of viral suppression with the risks of adverse events is critical for successful IFN therapy.
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