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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Plasmonic nanopipette biosensor.

Jean-Francois Masson¹, Julien Breault-Turcot, Rita Faid

¹Department of Chemistry, Université de Montréal , C.P. 6128 Succ. Centre-Ville, Montreal, QC, Canada , H3C 3J7.

Analytical Chemistry

|August 27, 2014

Summary

This study introduces a novel plasmonic nanobiosensor for detecting immunoglobulin G (IgG). The "patch clamp" nanopipette integrates surface-enhanced Raman scattering (SERS) for highly sensitive immunoassay detection.

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Area of Science:

Nanotechnology
Biomedical Engineering
Analytical Chemistry

Background:

Nanopipettes offer precise control at the nanoscale.
Surface-enhanced Raman scattering (SERS) is a sensitive detection technique.
Immunoglobulin G (IgG) is a crucial biomarker in various diseases.

Purpose of the Study:

To develop a SERS immunoassay integrated on a plasmonic nanopipette for IgG detection.
To optimize the nanobiosensor by investigating nanoparticle properties and plasmonic coupling.
To explore the potential of nanopipette-based nanobiosensors for monitoring biomolecules near cells.

Main Methods:

Fabrication of a plasmonic nanopipette with gold nanoparticles (AuNPs).
Implementation of a SERS sandwich immunoassay using AuNPs and anti-IgG antibodies.

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Systematic investigation of nanoparticle shape, surface coverage, reporter, pH, and plasmonic coupling.

Main Results:

Successful detection of IgG using the SERS immunoassay on the nanopipette.
Identification of optimal parameters for nanoparticle configuration and plasmonic coupling.
Demonstration of the nanobiosensor's potential for sensitive and specific IgG detection.

Conclusions:

The plasmonic nanopipette SERS immunoassay is a promising platform for IgG detection.
Optimized nanobiosensor design enhances sensitivity and understanding of plasmonic properties.
This technology has potential applications in cellular monitoring and diagnostics.