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Nontraditional risk factors for cardiovascular disease and visceral adiposity index among different body size

T Du1, J Zhang1, G Yuan1

  • 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|August 28, 2014
PubMed

Insights

Metabolically healthy obese (MHO) individuals show higher levels of non-traditional cardiovascular risk factors, including elevated apolipoprotein B and uric acid, compared to metabolically healthy normal-weight individuals. These findings suggest a potential increased cardiovascular disease risk in MHO populations.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Obesity Research

Background:

  • Cardiovascular disease (CVD) risk in metabolically healthy obese (MHO) individuals is debated.
  • Traditional risk factors may not fully capture metabolic abnormalities in MHO.
  • Novel biomarkers are needed to assess CVD risk in MHO.

Purpose of the Study:

  • To compare non-traditional CVD risk factors in various body size and metabolic phenotypes.
  • To investigate elevated lipoprotein (a), apolipoprotein B, uric acid (UA), apolipoprotein B/A1 ratio, and visceral adiposity index (VAI) in MHO individuals.

Main Methods:

  • Cross-sectional analysis of 7765 Chinese adults from the 2009 China Health and Nutrition Survey.
  • Comparison of risk factor prevalence across six body size phenotypes (normal weight, overweight, obese, with and without metabolic abnormalities).

Main Results:

  • MHO individuals exhibited intermediate prevalence of elevated apolipoprotein B, UA, and VAI, and low apolipoprotein A1 between metabolically healthy normal-weight (MHNW) and metabolically abnormal obese groups.
  • Elevated apolipoprotein B, UA, apolipoprotein B/A1 ratio, and VAI were significantly associated with the MHO phenotype.

Conclusions:

  • MHO individuals have a higher prevalence of elevated non-traditional CVD risk factors and VAI scores compared to MHNW individuals.
  • These elevated markers in MHO may contribute to the increased CVD risk observed in long-term studies.
  • Non-traditional risk factors are crucial for assessing CVD risk in MHO populations.
Abstract

Keywords:
Apolipoprotein A1Apolipoprotein BMetabolically abnormal and obeseMetabolically healthy but obese

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