Related Experiment Videos
Pharmacological modulation of 86Rb efflux from aortic endothelial cells
1Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Belgium.
Abstract:
The ATP-induced efflux of 86Rb from prelabelled bovine aortic endothelial cells was inhibited by quinine (50 microM) but not by a tetraethylammonium (5 mM) or apamin (50 nM). Neither sulfonylureas nor pinacidil had a significant effect on the rate of 86Rb efflux from the endothelial cells. These data are consistent with the presence of intermediate conductance Ca2(+)-activated K+ channels in endothelial cells. ATP-dependent K+ channels, sensitive to sulfonylureas and pinacidil, could not be detected.
Related Concept Videos
Aortic Regurgitation III: Medical Management
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include: