Multicomponent reactions in nucleoside chemistry

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Nucleoside Chemistry

Background:

• Nucleoside analogs are crucial in antiviral and anticancer therapies.
• Developing efficient synthetic routes for novel nucleoside analogs is an ongoing challenge.
• Multicomponent reactions (MCRs) provide a powerful platform for molecular complexity.

Purpose of the Study:

• To review and categorize recent applications of MCRs in nucleoside analog synthesis.
• To consolidate information on MCR strategies for both nucleoside modification and de novo scaffold construction.
• To present biochemical properties of synthesized analogs where available.

Main Methods:

• Systematic literature search of original publications on MCRs and nucleoside synthesis.
• Categorization of synthetic approaches based on established MCR classifications.
• Analysis of reported synthetic strategies and biochemical data.

Main Results:

• Sixty original publications detailing MCR applications in nucleoside analog synthesis were reviewed.
• MCRs were successfully employed for modifying parent nucleoside cores.
• MCRs facilitated the de novo construction of nucleoside scaffolds from simpler precursors.

Conclusions:

• Multicomponent reactions are highly effective for the synthesis of diverse nucleoside analogs.
• MCRs offer efficient and modular approaches for generating novel nucleoside structures.
• The reviewed MCR strategies hold significant potential for future drug discovery efforts in nucleoside chemistry.