Related Experiment Video
Updated: Apr 25, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Hematological changes in an elite climber over 18 years.
Gaizka Mejuto1, Julio Calleja-Gonzalez, Jose Antonio Lekue
11 Laboratory of Analysis of Sport Performance, Sport and Physical Education Department, Faculty of Sport Sciences, University of the Basque Country , Vitoria-Gasteiz, Alava, Spain .
Repeated high-altitude exposure increases red blood cell parameters in elite climbers. However, this hematological response to hypoxia attenuated over time in the studied climber.
Area of Science:
- Sports Medicine
- Altitude Physiology
Background:
- Elite athletes undergo rigorous training and exposure to extreme environments.
- Understanding physiological adaptations to high altitude is crucial for performance and health.
Observation:
- Red blood cell parameters, including hemoglobin and hematocrit, were monitored in an elite climber over 18 years.
- Measurements were taken before and after high-altitude expeditions.
Findings:
- A significant average increase of 15% in red blood cell parameters was observed following expeditions.
- A negative correlation between age and post-expedition results was noted (p<0.01).
- The hematological response to hypobaric hypoxia attenuated over the study period (p<0.01).
Implications:
- High-altitude exposure induces significant hematological changes in elite climbers.
- The attenuated response over time suggests acclimatization or other adaptive mechanisms.
- Further research is needed to confirm these findings in diverse populations.
Related Concept Videos
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Multipotency of Hematopoietic Stem Cells
Hematopoiesis
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...

