Related Experiment Video

Updated: Apr 25, 2026

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
15:54

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

Published on: June 14, 2014

27.4K

[Initiation of X chromosome inactivation during early embryogenesis in mice and in humans]

Catherine Patrat, Ikuhiro Okamoto, Edith Heard

    Bulletin De L'Academie Nationale De Medecine
    |August 29, 2014
    PubMed

    More Related Videos

    Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells07:34

    Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells

    Published on: January 10, 2014

    6.6K
    A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome08:27

    A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

    Published on: May 22, 2019

    6.0K

    Related Concept Videos

    X-inactivation01:58

    X-inactivation

    6.4K
    X-Inactivation01:58

    X-Inactivation

    The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
    38.8K
    Inheritance of Chromatin Structures03:17

    Inheritance of Chromatin Structures

    Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
    6.0K
    Dosage Compensation02:50

    Dosage Compensation

    In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
    In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will...
    6.3K
    The Ratio of X Chromosome to Autosomes02:45

    The Ratio of X Chromosome to Autosomes

    In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
    Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
    11.5K
    Epigenetic Regulation01:46

    Epigenetic Regulation

    Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
    28.7K