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Two doses of measles mumps rubella (MMR) vaccine

H Kuno-Sakai, K Ozaki, M Kimura

    Acta Paediatrica Japonica : Overseas Edition
    |December 1, 1989
    PubMed

    Insights

    A two-dose measles, mumps, and rubella (MMR) vaccine schedule in children aged 12-48 months achieved 100% seroconversion. This two-dose regimen is preferable for controlling measles, mumps, and rubella infections.

    Area of Science:

    • Pediatrics
    • Immunology
    • Vaccinology

    Background:

    • Single-dose measles vaccines have a non-negligible failure rate.
    • Combining vaccines in MMR may increase the frequency of vaccine failure.
    • Some children may not achieve adequate immunity after a single MMR dose.

    Purpose of the Study:

    • To evaluate the efficacy of a two-dose MMR vaccine schedule.
    • To determine if a two-dose schedule improves seroconversion rates.
    • To assess the optimal MMR vaccination strategy for children.

    Main Methods:

    • Administered a two-dose MMR vaccine schedule at a six-week interval.
    • Studied children aged 12 to 48 months.
    • Assessed seroconversion using measles hemagglutinin inhibition (HI) and rubella HI tests, and mumps ELISA.

    Main Results:

    • Achieved 100% seroconversion for measles, rubella, and mumps in both vaccine groups.
    • Identified that some children remained seronegative after one MMR dose.
    • Demonstrated that a two-dose MMR schedule reinforced immunity in non-responders.

    Conclusions:

    • A two-dose MMR vaccination schedule is highly effective in children aged 12-48 months.
    • Two doses of MMR are superior to a single dose for achieving and reinforcing immunity.
    • The findings support a two-dose MMR schedule for effective control of measles, mumps, and rubella.

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