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Related Experiment Video

Updated: Apr 25, 2026

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Published on: April 1, 2019

White matter hyperintensities and hypobaric exposure.

Stephen A McGuire¹, Paul M Sherman, S Andrea Wijtenburg

¹US Air Force School of Aerospace Medicine, Aerospace Medicine Consultation Division, Wright-Patterson Air Force Base, OH; Department of Neurology, University of Texas Health Sciences Center, San Antonio, TX; Department of Neurology, 59th Medical Wing, Lackland Air Force Base, TX.

Annals of Neurology

|August 29, 2014

Summary

This summary is machine-generated.

Occupational exposure to nonhypoxic hypobaric conditions is linked to subcortical white matter hyperintensities (WMHs). This finding suggests environmental factors may contribute to WMHs in healthy individuals.

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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Area of Science:

Neurology
Environmental Medicine
Occupational Health

Background:

Subcortical white matter hyperintensities (WMHs) are often associated with aging and cerebrovascular risk factors.
The role of environmental exposures, particularly nonhypoxic hypobaria, in WMH development is not well understood.

Purpose of the Study:

To investigate the association between occupational exposure to nonhypoxic hypobaria and the presence of subcortical WMHs.
To determine if individuals working in environments with reduced atmospheric pressure exhibit increased WMH burden.

Main Methods:

Utilized high-resolution MRI to assess subcortical WMH burden in 83 altitude chamber personnel (PHY) and 105 U-2 pilots (U2P).
Compared WMH counts and volumes in exposed groups to 148 age- and health-matched doctorate degree controls (DOC).
Quantified WMH burden after stereotactic transformation of MRI images to the Talairach atlas.

Main Results:

Subcortical WMHs were significantly more prevalent in both PHY and U2P groups compared to the DOC group.
WMH volume and count were elevated in U2P (p < 0.001) and PHY (p = 0.011/0.019) relative to controls.
No significant difference in WMH prevalence was observed between the PHY and U2P groups.

Conclusions:

Occupational nonhypoxic hypobaric exposure is associated with an increased prevalence of subcortical WMHs in a young, healthy population.
This study identifies nonhypoxic hypobaria as a potential environmental risk factor for WMH development.
Findings contribute to understanding environmentally induced brain changes and support further research into occupational hazards affecting neurological health.