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Pseudomonas peritonitis in CAPD patients: characteristics and outcome of treatment
Abstract:
Twenty-five episodes of Pseudomonas peritonitis which occurred over a five-and-a-half-year period were reviewed. Pseudomonas peritonitis accounted for 25/516 (4.8%) of all episodes of peritonitis. Nine of the episodes were first infections in that the patient had not experienced peritonitis before. The rest were repeat peritonitis. There was no difference in any demographic factors between the first episodes and the repeat episodes except exit site infection which was more common among patients who had repeat infections. Overall cure rate of Pseudomonas peritonitis was 20/25 (80%). Five catheters had to be removed, all in patients who had to be transferred permanently to haemodialysis. In general, ceftazidime in combination with an aminoglycoside was an effective regimen. Oral ofloxacin was not useful despite in vitro sensitivity of the pathogen to the antibiotic.
Insights
Pseudomonas peritonitis, a complication in dialysis patients, was treated effectively with ceftazidime and an aminoglycoside. Oral ofloxacin showed limited efficacy despite in vitro sensitivity.
Area of Science:
- Nephrology
- Infectious Diseases
- Clinical Microbiology
Background:
- Pseudomonas peritonitis is a serious complication in patients undergoing peritoneal dialysis.
- Understanding treatment outcomes and risk factors is crucial for patient management.
Purpose of the Study:
- To review episodes of Pseudomonas peritonitis in peritoneal dialysis patients.
- To evaluate treatment efficacy and identify factors associated with repeat infections.
Main Methods:
- Retrospective review of 25 episodes of Pseudomonas peritonitis over 5.5 years.
- Analysis of demographic factors, infection history, treatment regimens, and outcomes.
Main Results:
- Pseudomonas peritonitis represented 4.8% of all peritonitis episodes.
- Exit site infection was more common in repeat infections.
- An 80% cure rate was achieved with ceftazidime plus an aminoglycoside; oral ofloxacin was ineffective.
Conclusions:
- Ceftazidime combined with an aminoglycoside is an effective treatment for Pseudomonas peritonitis.
- Repeat peritonitis episodes may be associated with exit site infections.
- Oral ofloxacin is not recommended for Pseudomonas peritonitis despite in vitro sensitivity.