Related Experiment Video
Updated: Apr 25, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Increased lactate threshold after five weeks of treadmill aerobic training in rats
W H Brito Vieira1, M J E Halsberghe2, M L B Schwantes2
1Department of Physical Therapy, Federal University of Rio Grande do Norte - UFRN, Natal, RN, Brazil.
Aerobic treadmill training improved running performance and lactate threshold (LT) in rats. This study demonstrates that LT can be measured in rats and is enhanced by endurance exercise.
Area of Science:
- Physiology
- Exercise Science
Background:
- Lactate threshold (LT) is a key indicator of aerobic fitness.
- Understanding LT in animal models aids in studying exercise physiology.
Purpose of the Study:
- To analyze changes in lactate threshold (LT) in rats following an aerobic treadmill training program.
- To investigate the physiological adaptations to aerobic exercise in a rodent model.
Main Methods:
- Twenty-five Wistar rats were divided into sedentary control and trained groups.
- The trained group underwent a 5-week aerobic treadmill training program.
- An incremental exercise test was used to determine LT and maximum running speed.
Main Results:
- Trained rats showed a significant increase in maximum running speed and running speed at LT.
- Blood lactate levels at LT were reduced in the trained group.
- Aerobic training induced positive oxidative physiological adaptations.
Conclusions:
- Lactate threshold can be reliably determined in rats.
- Aerobic training significantly enhances LT and running performance in rats.
- Endurance exercise elicits beneficial physiological adaptations relevant to oxidative capacity.
More Related Videos
09:19Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
Published on: February 2, 2019
10:19Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014