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[Au]/[Pd] Multicatalytic processes: direct one-pot access to benzo[c]chromenes and benzo[b]furans
Yoshihiro Oonishi1, Adrián Gómez-Suárez, Anthony R Martin
1EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST (UK), Fax: (+44) 1334-463808; Current address: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812 (Japan).
Abstract:
A new synthetic protocol that combines the advantages offered by eco-friendly solvent-free reactions and sequential transformations is reported. This strategy offers straightforward access to benzo[c]chromenes and benzo[b]furans from commercially available starting materials. This two-step, one-pot strategy consists of an Au-catalyzed hydrophenoxylation process followed by Pd-catalyzed C-H activation or Mizoroki-Heck reactions. The selectivity of the process towards C-H activation or Mizoroki-Heck reaction can be easily tuned.
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