Related Experiment Video

Updated: Apr 25, 2026

A Murine Model of Carotid Aneurysm Formation
03:47

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

485

Morphological, hemodynamic, and clinical independent risk factors for anterior communicating artery aneurysms

Wojciech Kaspera1, Piotr Ładziński2, Patrycja Larysz2

  • 1From the Department of Neurosurgery, Medical University of Silesia, Regional Hospital, Sosnowiec, Poland (W.K., P.Ł., P.L., M.K.); Radiodiagnostic Department (A.H.) and Department of Radiotherapy (D.L.), Maria Skłodowska-Curie Memorial Cancer Center, Institute of Oncology, Gliwice, Poland; and Radiodiagnostic Department, Specialist Hospital, Jaworzno, Poland (K.P.). wkaspera@wp.pl.

Stroke
|August 30, 2014
PubMed

Insights

Smoking, hypertension, and specific anatomical variations are key risk factors for developing anterior communicating artery aneurysms. Understanding these factors, including blood flow pulsatility and vessel angles, aids in predicting and potentially preventing aneurysm formation.

Area of Science:

  • Neuroscience
  • Vascular Surgery
  • Radiology

Background:

  • Cerebral aneurysm pathogenesis remains debated.
  • Anterior communicating artery (ACoA) aneurysms present unique etiological questions.

Purpose of the Study:

  • Identify independent risk factors for ACoA aneurysm development.
  • Investigate morphological, hemodynamic, and clinical contributors.

Main Methods:

  • CT angiography and transcranial sonography in 77 ACoA aneurysm patients and 73 controls.
  • Assessed A1 segment symmetry, A1-A2 angles, tortuosity, diameter, mean velocity, pulsatility index, and flow rate.
  • Multivariate logistic regression analysis to determine independent risk factors.

Main Results:

  • Univariate analysis linked smoking, hypertension, A1 asymmetry, A1-A2 angle, A1 diameter, Vm, pulsatility index, and flow rate to aneurysm occurrence.
  • Multivariate analysis identified smoking (OR 2.04), A1 asymmetry >40% (OR 2.52), low pulsatility index (OR 0.004), and A1-A2 angle ≤100° (OR 4.67) as strong independent risk factors.

Conclusions:

  • ACoA aneurysm risk is multifactorial, involving clinical, morphological, and hemodynamic elements.
  • Strongest independent predictors include smoking, significant A1 asymmetry, low blood flow pulsatility, and specific A1-A2 angles.
Abstract

Keywords:
anterior cerebral arteryhemodynamicsintracranial aneurysmmultidetector computed tomographyrisk factorsultrasonography, doppler, transcranial

More Related Videos

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms11:58

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms

Published on: August 11, 2015

15.5K
Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment18:50

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment

Published on: September 25, 2009

13.1K

Related Concept Videos

The Arch of Aorta01:10

The Arch of Aorta

The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
2.2K
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
648
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
585
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
478
Arteries of the Head and Neck01:26

Arteries of the Head and Neck

The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
4.3K